✅REDUCES SEROTONIN DURING STRESS:
Serotonin is a HIBERNATION neurotransmitter, it slows metabolism, increases prolactin and rises alongside ENDOTOXIN and ESTROGEN (Yamada et al., 2003). It is PRO-Inflammatory (Ray Peat, 2019) and wrecks havoc on thyroid function. Coffee has been shown to prevent the rise of serotonin during stress, whilst positively increasing dopamine (Yamato et al., 2002).
❌DOES NOT INCREASE CORTISOL:
Cortisol synthesis depends on the enzyme 11β-HSD1 and it converts the inactive cortisone into the active cortisol.
Big Pharma is in hot pursuit of an effective and selective 11β-HSD1 inhibitor as a treatment of obesity, diabetes, Cushing syndrome, depression, mania, and a few other serious conditions.
An unknown compound in coffee to be a strong inhibitor 11β-HSD1 (Atanasov et al., 2006).
❤️INCREASES THE HORMONE PROGESTERONE:
Caffeine synergizes with progesterone, and increases its concentration in blood and tissues. Progesterone is VITAL for mood, calmness and overall health (Peat, 2019). It is a protective hormone.
⚡️INHIBITS IRON ABSORPTION:
Coffee inhibits iron absorption if taken with meals, helping to prevent iron overload (Jones et al., 2009).
Caffeine enhances motivation due to its ability to make the Dopamine D2 receptors in the striatum (main pathway for increasing motivation) more sensitive (Volkow et al., 2015).
👎🏽WHY IT MIGHT MAKE YOU MORE STRESSED:
If you are someone who feels MORE stressed after coffee, this is likely due to, either, poor liver function, low COMT activity, high baseline adrenaline, low GABA, low magnesium, low B1, hypoglycaemia, empty stomach.
Coffee has a plethora of health benefits, however, as always, its up to bio individuality. Timing your coffee is also important.