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Benefits
Adrafinil is a stimulant based eugeroic that can increase energy, prevent fatigue, and enhance wakefulness, without causing anxiety or other side effects that are typically associated with stimulants. It may also improve mood, focus, and learning ability, and may even help keep your brain healthy.
Brain
•The mechanism of adrafinil appears to rely on postsynaptic α-adrenergic activity, since an increase in locomotion caused by adrafinil is blocked by prazosin (α1 antagonist), yohimbine (α2 antagonist), or phenoxybenzamine (mixed α-antagonist) (1).
•Blocking the synthesis of catecholamines (with α-methyltyrosine) does not prevent the actions of adrafinil, providing further evidence differentiating the actions of adrafinil as distinct from that of amphetamine-like stimulants (2).
•Since adrafinil lacks anxiogenic (anxiety producing) effects and has greater efficacy during periods when research animals would typically be asleep, the effect of adrafinil on locomotion is thought to be secondary to promoting wakefulness (3).
•It stimulates histamine (HA), norepinephrine (NE), serotonin (5-HT), dopamine (DA), and orexin systems in the brain (4).
Energy
•Via acting as a potential dopamine reuptake inhibitor, it blocks the mechanism by which dopamine is absorbed by the body and rendered inert, thereby enhancing energy levels (5).
•Adrafinil operates much the same way as amphetamines when it comes to keeping you awake and alert, without the major side effects (6).
How to use
Adrafinil (Liquid Nootropic)
250mg - 400mg
250mg - 400mg
Need to find the right dose for you? Consider coaching.
Dosing strategy:
Best used infrequently. However, chronic use of adrafinil can be considered as not addictive with a low potential for abuse. Tolerance to many of the effects of adrafinil develops with prolonged and repeated use.
Ideal for:
Students, entrepreneurs.
Quality
All vendors are vetted for quality, to ensure they contain the right active ingredients and ratios. Each vendor provides a Certificate of Analysis ℹ️, to ensure accurate dosing, and a product free of contaminants/heavy metals. Further, when brands we work with have been randomly pulled off the shelf and tested by Labdoor, they have tended to score A+ ℹ️.
Efficacy
Before listing products, we compile a list of available research, to determine if claims match the evidence. Likewise, we scour the the internet to gauge people’s experience with each product. Most of the products listed typically score at least [4.5/5 from reviews]. All the studies we’ve found are listed at the bottom of the page, under citations.
Safety
All products listed on the BYB website follow screening before listing, to ensure there’s a history of long-term usage without adverse effects. Many products fall under the FDA’s Generally Recognized as Safe (GRAS) guidelines.
Medication interactions and allergies
Please consult your healthcare professional before making any changes to your lifestyle or regime.
For further information on contraindications and allergies, please visit the vendors website.
Buy from a BYB
With a half life of 15 hours, this will keep you awake and alert. So watch out! Adrafinil supplementation increases alertness and wakefulness. Adrafinil is a stimulant, but it does not cause hyperactivity. Instead, it fights sleepiness.
I am yet to personally experiment with adrafinil, however, in the past I have used modafinil and noticed incredible effects for wakefulness and alertness.
